Late chronotype is linked to greater cortical thickness in the left fusiform and entorhinal gyri

Humans can be classified as early, intermediate and late chronotypes based on their preferred sleep wakefulness patterns. Eveningness is associated with increased risk of developing several psychiatric conditions, such major depressive addictive disorders, however, the anatomical basis chronotype distinctions, which might predispose to above remains largely unexplored. Using magnetic resonance imaging data from 113 healthy young adults (71 females), we aimed correlate individual scores cortical thickness, well subcortical cerebellar grey matter volume. The results revealed one cluster located in left fusiform entorhinal gyri showing thickness increasing preference for eveningness. These structures are positioned mediate well-established differences affective processing, i.e. negative affect chronotypes. Furthermore, line earlier findings, found no Thus, our study confirms that circadian specific structural substrates provides a potential differential functioning morning- evening-oriented individuals, bridging gap between brain structure function.